Early efforts from Spinazzola and Rrahmani earned a 2-0 triumph for the visitors at Lazio in a fixture overshadowed by multiple sendings-off.
The win propels Napoli to within a single point of Serie A leaders AC Milan, who won on Friday. Inter hold third place but can return to the top with a win in their later match.
Despite missing several injured players, the southern Italian side controlled the game with patient attacks. The first goal arrived when Matteo Politano's delivery was drilled home by the wing-back at the far post.
The advantage was doubled in the 32nd minute as the defender guided a header from another Politano set-piece into the bottom corner. They went close to a third shortly after when Elmas watched his effort crash against the crossbar.
After the break saw more worry for the visitors when a winger was forced off. This incident sparked a short confrontation, resulting in yellow cards for a Napoli defender and the home side's Noslin—who subsequently received a second yellow for a foul.
"I must congratulate my players, playing with this level of quality and intensity while preventing the opposition play is not easy," remarked the winning manager. "We played at a exceptional level of quality."
Tensions flared again late on as players from both sides became involved in a heated exchange, requiring the manager to intervene. The two players were sent off for their involvement in the clash.
Over in La Liga, the Andalusian side suffered a heavy loss at home to struggling the Granotas. The visitors took control with a fine move before adding two further goals in the second period to seal a comprehensive win.
In other news, Real Madrid face significant must-win when they play Betis, after their rivals extended their advantage at the summit. Later on other match, Atleti travel to face Real Sociedad.
Turning to Ligue 1, a historic capital clasico takes place as the newly-promoted side visit powerhouses Paris Saint-Germain. The fixture marks the first top-flight encounter between the two clubs in decades, adding significant spice to the weekend's action.
